Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.
J Clin Endocrinol Metab. 2012 Jul;97(7):E1099-105. doi: 10.1210/jc.2011-3243. Epub 2012 Apr 16.
The intramyocellular deposition of lipid associates with metabolic dysregulation in adolescents and adults. Relatively little is known about the deposition of fat in muscle before the onset of puberty.
Our objective was to describe the relationship between intramyocellular lipid (IMCL) accumulation and 1) visceral adiposity and 2) markers of insulin resistance and cardiovascular disease risk in a cohort of prepubertal and early pubertal children.
Data were collected as part of a retrospective cohort study, Exploring Perinatal Outcomes among Children (EPOCH). Multiple linear regression models were constructed for data analysis.
A total of 441 children participated in the study (226 prepubertal, 215 early pubertal). In prepubertal children, there was a significant relationship between IMCL and visceral fat (parameter estimate 0.019, P = 0.002) that remained after controlling for body mass index. Independent of overall adiposity, in all children, IMCL was associated with the triglyceride to high-density lipoprotein ratio (parameter estimate 0.1418, P = 0.002).
This study demonstrates a concerning and related pattern of IMCL and visceral fat deposition in prepubertal children. Intramuscular fat deposition is linked to markers of insulin resistance and cardiovascular disease risk.
肌细胞内脂肪沉积与青少年和成年人的代谢失调有关。在青春期前，关于肌肉中脂肪的沉积，人们知之甚少。
我们的目的是描述肌细胞内脂质（IMCL）堆积与 1）内脏肥胖和 2）胰岛素抵抗和心血管疾病风险标志物之间的关系，该研究队列包括青春期前和早期青春期的儿童。
数据是作为探索围产期儿童结局（EPOCH）的回顾性队列研究的一部分收集的。采用多元线性回归模型进行数据分析。
共有 441 名儿童参与了这项研究（226 名青春期前，215 名早期青春期）。在青春期前的儿童中，IMCL 与内脏脂肪之间存在显著的关系（参数估计值 0.019，P = 0.002），在控制体重指数后仍然存在这种关系。独立于整体肥胖，所有儿童的 IMCL 与甘油三酯与高密度脂蛋白比值相关（参数估计值 0.1418，P = 0.002）。
这项研究表明，青春期前儿童的 IMCL 和内脏脂肪沉积存在令人担忧的相关模式。肌肉内脂肪沉积与胰岛素抵抗和心血管疾病风险的标志物有关。
