Braun School of Public Health and Community Medicine, Hebrew University-Hadassah Faculty of Medicine, Jerusalem, Israel.
J Pediatr. 2011 Jan;158(1):44-50. doi: 10.1016/j.jpeds.2010.07.002.
To assess whether the fasting triglyceride-to-high-density lipoprotein (HDL)-cholesterol (TG/HDL) ratio in adolescence is predictive of a proatherogenic lipid profile in adulthood.
A longitudinal follow-up of 770 Israeli adolescents 16 to 17 years of age who participated in the Jerusalem Lipid Research Clinic study and were reevaluated 13 years later. Lipoprotein particle size was assessed at the follow-up with proton nuclear magnetic resonance.
The TG/HDL ratio measured in adolescence was strongly associated with low-density lipoprotein, very low-density lipoprotein (VLDL), and HDL mean particle size in young adulthood in both sexes, even after adjustment for baseline body mass index and body mass index change. The TG/HDL ratio measured in adolescence and subsequent weight gain independently predicted atherogenic small low-density lipoprotein and large VLDL particle concentrations (P < .001 in both sexes). Baseline TG/HDL and weight gain interacted to increase large VLDL concentration in men (P < .001).
Adolescents with an elevated TG/HDL ratio are prone to express a proatherogenic lipid profile in adulthood. This profile is additionally worsened by weight gain.
评估青少年时期的空腹甘油三酯与高密度脂蛋白胆固醇（TG/HDL）比值是否可预测成年后具有致动脉粥样硬化作用的脂质谱。
对 770 名 16 至 17 岁的以色列青少年进行了纵向随访，这些青少年参加了耶路撒冷脂质研究诊所研究，并在 13 年后再次进行评估。在随访时使用质子磁共振对脂蛋白颗粒大小进行了评估。
在两性中，青少年时期测量的 TG/HDL 比值与年轻成年人的低密度脂蛋白（LDL）、极低密度脂蛋白（VLDL）和 HDL 平均颗粒大小呈强相关，即使在校正基线体重指数和体重指数变化后也是如此。青少年时期测量的 TG/HDL 比值和随后的体重增加独立预测致动脉粥样硬化的小而密 LDL 和大 VLDL 颗粒浓度（两性均 P<0.001）。TG/HDL 的基线比值和体重增加相互作用，使男性的大 VLDL 浓度增加（P<0.001）。
青少年时期 TG/HDL 比值升高者，成年后易出现致动脉粥样硬化的脂质谱。体重增加进一步加重了这种情况。
