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Synaptic potentiation onto habenula neurons in the learned helplessness model of depression.在习得性无助抑郁模型中,突触增强到缰核神经元。
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超越抑郁症:迈向基于过程的研究、诊断和治疗方法。

Beyond Depression: Towards a Process-Based Approach to Research, Diagnosis, and Treatment.

作者信息

Forgeard Marie J C, Haigh Emily A P, Beck Aaron T, Davidson Richard J, Henn Fritz A, Maier Steven F, Mayberg Helen S, Seligman Martin E P

机构信息

Department of Psychology, University of Pennsylvania.

出版信息

Clin Psychol (New York). 2011 Dec;18(4):275-299. doi: 10.1111/j.1468-2850.2011.01259.x.

DOI:10.1111/j.1468-2850.2011.01259.x
PMID:22509072
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3325764/
Abstract

Despite decades of research on the etiology and treatment of depression, a significant proportion of the population is affected by the disorder, fails to respond to treatment and is plagued by relapse. Six prominent scientists, Aaron Beck, Richard Davidson, Fritz Henn, Steven Maier, Helen Mayberg, and Martin Seligman, gathered to discuss the current state of scientific knowledge on depression, and in particular on the basic neurobiological and psychopathological processes at play in the disorder. These general themes were addressed: 1) the relevance of learned helplessness as a basic process involved in the development of depression; 2) the limitations of our current taxonomy of psychological disorders; 3) the need to work towards a psychobiological process-based taxonomy; and 4) the clinical implications of implementing such a process-based taxonomy.

摘要

尽管对抑郁症的病因和治疗进行了数十年的研究,但仍有相当一部分人受到这种疾病的影响,对治疗没有反应且饱受复发困扰。六位杰出科学家,亚伦·贝克、理查德·戴维森、弗里茨·亨恩、史蒂文·迈尔、海伦·梅伯格和马丁·塞利格曼,齐聚一堂讨论抑郁症的科学知识现状,尤其是该疾病中起作用的基本神经生物学和精神病理学过程。讨论了以下几个总体主题:1)习得性无助作为抑郁症发展中涉及的基本过程的相关性;2)我们当前心理障碍分类法的局限性;3)建立基于心理生物学过程的分类法的必要性;4)实施这种基于过程的分类法的临床意义。