TB Control Unit, Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, Singapore.
Singapore Med J. 2012 Apr;53(4):238-40.
The global emergence of multidrugresistant (MDR) tuberculosis (TB) and extensively drug-resistant (XDR)-TB threatens to derail the efforts of TB control programmes worldwide. From 2000 to 2010, 161 pulmonary MDR-TB cases (including six XDR-TB cases) were reported in Singapore, and of these, 80% occurred among the foreign-born, with an increasing trend seen after 2004. Among new pulmonary TB cases, the highest incidence of MDR-TB occurred among patients from Myanmar (8%), followed by Vietnam (4.4%) and China (2.3%), while among those previously treated, the highest incidence was found in patients from Vietnam (50%), followed by Indonesia (33%) and Bangladesh (33%). Although the proportion of Singapore-born pulmonary TB cases with MDR-TB has remained comparatively low (0.2% and 1.3% in new and previously treated cases, respectively), there is no room for complacency. Top priority must be accorded toward the proper treatment of drug-susceptible TB cases under strict programme conditions so as to prevent the development of MDR-TB in the first place.
全球耐多药（MDR）结核病（TB）和广泛耐药（XDR）-TB 的出现，威胁着全球结核病控制规划的努力。从 2000 年到 2010 年，新加坡报告了 161 例肺部 MDR-TB 病例（包括 6 例 XDR-TB 病例），其中 80%发生在外国出生的人群中，2004 年后呈上升趋势。在新的肺结核病例中，缅甸（8%）的 MDR-TB 发病率最高，其次是越南（4.4%）和中国（2.3%），而在既往治疗的病例中，越南（50%）的发病率最高，其次是印度尼西亚（33%）和孟加拉国（33%）。尽管新加坡出生的肺结核病例中 MDR-TB 的比例相对较低（新发病例和既往治疗病例中分别为 0.2%和 1.3%），但仍不能掉以轻心。必须优先考虑在严格的规划条件下对药物敏感的结核病病例进行适当治疗，以防止首先出现 MDR-TB。
