使用碱金属溴化物通过 C-H 键抽取代烷基芳烃的直接和选择性苄基氧化。
Direct and selective benzylic oxidation of alkylarenes via C-H abstraction using alkali metal bromides.
机构信息
Graduate School of Science, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba 263-8522, Japan.
出版信息
Org Lett. 2012 May 4;14(9):2414-7. doi: 10.1021/ol300853z. Epub 2012 Apr 18.
PMID:22512904
Abstract
A direct benzylic oxidation of alkylarenes via C-H bond abstraction was developed using alkali metal bromides and oxidants under mild conditions. This reaction proceeded with excellent selectivity by thermal oxidation or photooxidation to provide a broad range of carbonyl compounds containing electron-deficient aryl carbonyl compounds in high yields.
摘要
发展了一种在温和条件下使用碱金属溴化物和氧化剂通过 C-H 键断裂实现的烷基芳烃的直接苄基氧化反应。该反应通过热氧化或光氧化进行，具有极好的选择性，以高产率提供了广泛的含有缺电子芳基羰基化合物的羰基化合物。
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