Equipe Différenciation Neuronale et Gliale, Université Pierre et Marie Curie Paris, France.
Front Neuroanat. 2012 Apr 11;6:11. doi: 10.3389/fnana.2012.00011. eCollection 2012.
Between the first and the second postnatal week, the development of rodent Purkinje cells is characterized by several profound transitions. Purkinje cells acquire their typical dendritic "espalier" tree morphology and form distal spines. During the first postnatal week, they are multi-innervated by climbing fibers and numerous collateral branches sprout from their axons, whereas from the second postnatal week, the regression of climbing fiber multi-innervation begins, and Purkinje cells become innervated by parallel fibers and inhibitory molecular layer interneurons. Furthermore, their periods of developmental cell death and ability to regenerate their axon stop and their axons become myelinated. Thus a Purkinje cell during the first postnatal week looks and functions differently from a Purkinje cell during the second postnatal week. These fundamental changes occur in parallel with a peak of circulating thyroid hormone in the mouse. All these features suggest to some extent an interesting analogy with amphibian metamorphosis.
在第一到第二周之间，啮齿动物浦肯野细胞的发育以几个深刻的转变为特征。浦肯野细胞获得了它们典型的树突“格子”形态，并形成了远端棘突。在第一周，它们被 climbing fibers 多神经支配，并且它们的轴突上会生出许多侧支；而从第二周开始，climbing fiber 多神经支配开始退化，浦肯野细胞被平行纤维和抑制性分子层中间神经元支配。此外，它们的发育性细胞死亡期和再生轴突的能力停止，它们的轴突被髓鞘化。因此，第一周的浦肯野细胞看起来和功能与第二周的浦肯野细胞不同。这些根本的变化与老鼠中循环甲状腺激素的峰值同时发生。所有这些特征在某种程度上都与两栖动物变态形成了有趣的类比。
