Nagayama Yuji
Department of Molecular Medicine, Radiation Life Science Unit, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences.
Nihon Rinsho. 2012 Mar;70(3):436-40.
The thyroid glands are a vulnerable organ to ionizing radiation. Indeed the epidemiological studies have revealed an increase in the incidences of thyroid cancer among atomic bomb survivors in Hiroshima and Nagasaki and radiation casualties in Chernobyl. The carcinogenic risk for the thyroids is dependent on radiation dose, and higher in younger people. Recent advances in molecular biology contribute to clarify the mechanisms for thyroid carcinogenesis at genetic and molecular levels. Here radiation-induced thyroid carcinogenesis is reviewed from epidemiological data to basic research.
甲状腺是对电离辐射敏感的器官。事实上，流行病学研究显示，广岛和长崎原子弹爆炸幸存者以及切尔诺贝利核事故辐射受害者中甲状腺癌的发病率有所上升。甲状腺的致癌风险取决于辐射剂量，且在年轻人中更高。分子生物学的最新进展有助于从基因和分子层面阐明甲状腺癌发生的机制。本文从流行病学数据到基础研究对辐射诱导的甲状腺癌发生进行综述。
