Iavich M P, Rozhitskaia I I, Golubeva L Iu, Meerson F Z
Vopr Med Khim. 1990 Sep-Oct;36(5):8-11.
Distinct alterations in the rate of DNA synthesis (an increase in the rate of reparation and a decrease in the rate of replication in nuclei and mitochondria) were detected in liver and brain cells during the stress caused by surgical operation. Within 8-10 hrs after the operation the rate of DNA reparation was increased by 40-50% in nuclei of liver cells and by 31-35% in brain cell nuclei. Replication of nuclear DNA was decreased immediately after the operation--by 33% in liver cells and by 50% in brain cells. Within a day after the operation the rate of replication was restored up to the control level in liver cells, while it was still decreased by 30% in brain cells. The rate of mitochondrial DNA synthesis was slightly decreased within the first 12 hrs after the operation: by 12-14% in liver cells and by 18-20% in brain cells. The stress, and particularly postoperative stress, exhibited pronounced action on structure and various systems of DNA synthesis in cells of various tissues.
在外科手术引起的应激过程中，在肝细胞和脑细胞中检测到DNA合成速率的明显改变（修复速率增加，细胞核和线粒体中的复制速率降低）。术后8 - 10小时内，肝细胞细胞核中的DNA修复速率增加了40 - 50%，脑细胞细胞核中的DNA修复速率增加了31 - 35%。术后细胞核DNA的复制立即减少——肝细胞中减少了33%，脑细胞中减少了50%。术后一天内，肝细胞中的复制速率恢复到对照水平，而脑细胞中的复制速率仍比对照水平低30%。术后最初12小时内线粒体DNA合成速率略有下降：肝细胞中下降了12 - 14%，脑细胞中下降了18 - 20%。这种应激，尤其是术后应激，对各种组织细胞中DNA合成的结构和各种系统表现出显著作用。
