Gomes Enéas R M, Santos Robson A S, Guatimosim Silvia
Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil.
Int J Hypertens. 2012;2012:493129. doi: 10.1155/2012/493129. Epub 2012 Mar 4.
The Renin-Angiotensin System (RAS) acts at multiple targets and has its synthesis machinery present in different tissues, including the heart. Actually, it is well known that besides Ang II, the RAS has other active peptides. Of particular interest is the heptapeptide Ang-(1-7) that has been shown to exert cardioprotective effects. In this way, great compilations about Ang-(1-7) actions in the heart have been presented in the literature. However, much less information is available concerning the Ang-(1-7) actions directly in cardiomyocytes. In this paper, we show the actual knowledge about Ang-(1-7)-mediated signaling in cardiac cells more specifically we provide a brief overview of ACE2/Ang-(1-7)/Mas axis; and highlight the discoveries made in cardiomyocyte physiology through the use of genetic approaches. Finally, we discuss the protective signaling induced by Ang-(1-7) in cardiomyocytes and point molecular determinants of these effects.
肾素-血管紧张素系统（RAS）作用于多个靶点，其合成机制存在于包括心脏在内的不同组织中。实际上，众所周知，除了血管紧张素II（Ang II）外，RAS还有其他活性肽。特别值得关注的是七肽Ang-(1-7)，它已被证明具有心脏保护作用。通过这种方式，文献中已经出现了关于Ang-(1-7)在心脏中作用的大量综述。然而，关于Ang-(1-7)直接在心肌细胞中的作用的信息却少得多。在本文中，我们更具体地展示了关于Ang-(1-7)介导的心脏细胞信号传导的实际知识，我们简要概述了ACE2/Ang-(1-7)/Mas轴；并强调了通过使用基因方法在心肌细胞生理学中取得的发现。最后，我们讨论了Ang-(1-7)在心肌细胞中诱导的保护信号，并指出这些作用的分子决定因素。
