Graduate Program in Pharmaceutical Sciences and Department of Drugs and Pharmaceuticals, School of Pharmaceutical Sciences, São Paulo State University, UNESP, Araraquara, São Paulo, Brazil.
Drug Dev Ind Pharm. 2013 Feb;39(2):284-9. doi: 10.3109/03639045.2012.679278. Epub 2012 Apr 21.
Polymers mixtures as well as cross-linking reactions are approaches that have been used successfully to modulate the polymers characteristics in order to improve the control over drug release rate. High amylose and pectin are polysaccharides frequently used to prepare drug delivery systems. Since the drying technique can strongly influence the properties of such systems, the aim of this work was to characterize high amylose/pectin mixtures cross-linked with sodium trimetaphosphate and dried by different techniques - oven and lyophilization. The results showed that samples dried by lyophilization presented reduced particle size, higher porosity and higher swelling ability than the samples dried in oven. Besides, lower thermal stability and different diffraction patterns showed by the former particles should reflect the structural changes as a function of drying technique.
聚合物混合物以及交联反应是成功用于调节聚合物特性的方法，以改善对药物释放速率的控制。高直链淀粉和果胶是常用于制备药物传递系统的多糖。由于干燥技术会强烈影响此类系统的性质，因此本工作的目的是对用三聚磷酸钠交联的高直链淀粉/果胶混合物进行表征，并通过不同的技术（烤箱和冻干）进行干燥。结果表明，与在烤箱中干燥的样品相比，冻干干燥的样品具有更小的粒径、更高的孔隙率和更高的溶胀能力。此外，前者颗粒表现出的较低热稳定性和不同的衍射模式应该反映出作为干燥技术函数的结构变化。
