Anal Chem. 2012 May 15;84(10):4245-7. doi: 10.1021/ac300606n. Epub 2012 May 1.
Electrochemical impedance spectroscopy (EIS) is used to detect 2,4,6-trinitrotoluene (TNT) in a novel sandwiched structure which relies on the specific interactions between (i) primary amine with TNT and (ii) TNT and anti-TNT aptamer. With pure targets, the assay has a sensitivity of 10(-14) M, a dynamic range of 10(-14)-10(-3) M, and employs a small sample volume (25 μL). The method's sensitivity is comparable to state of the art optical methods with the added advantages of electrochemical detection, which can be easily miniaturized and implemented into a hand-held device.
电化学阻抗谱（EIS）用于检测新型夹层结构中的 2,4,6-三硝基甲苯（TNT），该结构依赖于（i）伯胺与 TNT 之间以及（ii）TNT 与抗 TNT 适体之间的特定相互作用。对于纯目标物，该测定法的灵敏度为 10(-14) M，动态范围为 10(-14)-10(-3) M，并且使用的样品体积较小（25 μL）。该方法的灵敏度可与最先进的光学方法相媲美，电化学检测具有易于小型化并集成到手持设备中的优点。
