Barnabas Mary Jenisha, Parambadath Surendran, Nagappan Saravanan, Ha Chang-Sik
Department of Polymer Science and Engineering, Pusan National University, Geumjeong-gu, Busan, 46241, Republic of Korea.
Heliyon. 2019 Apr 19;5(4):e01521. doi: 10.1016/j.heliyon.2019.e01521. eCollection 2019 Apr.
Cobalt (Co(II)) and copper (Cu(II)) complexes of sulfamerazine-salicylaldehyde (SS) ligand intercalated Mg/Al-layered double hydroxide [Co-SS-LDH/Cu-SS-LDH] were prepared for the antimicrobial application. Sulfamerazine and salicylaldehyde were mixed together and dissolved in methanol for the synthesis of SS ligand and modified further by the complexation with Co(II) and Cu(II) metal ions [Co-SS/Cu-SS]. The delaminating/restacking method was used to intercalate the Mg/Al-NO-LDH with the metal complexed ligands (Co-SS/Cu-SS). The obtained materials were analyzed using different characterization techniques to prove their successful synthesis and preparation. The antibacterial activity of the synthesized Co-SS-LDH/Cu-SS-LDH were checked by the inhibition zone method. The prepared hybrid materials showed good antimicrobial activity against both gram negative () and gram positive () bacteria.
为了抗菌应用，制备了磺胺甲基嘧啶 - 水杨醛（SS）配体插层的Mg/Al层状双氢氧化物的钴（Co(II)）和铜（Cu(II)）配合物[Co-SS-LDH/Cu-SS-LDH]。将磺胺甲基嘧啶和水杨醛混合并溶解在甲醇中以合成SS配体，并通过与Co(II)和Cu(II)金属离子[Co-SS/Cu-SS]络合进一步改性。采用剥离/重堆积法将Mg/Al-NO-LDH与金属络合配体（Co-SS/Cu-SS）插层。使用不同的表征技术对所得材料进行分析，以证明其成功合成和制备。通过抑菌圈法检测合成的Co-SS-LDH/Cu-SS-LDH的抗菌活性。所制备的杂化材料对革兰氏阴性菌（）和革兰氏阳性菌（）均显示出良好的抗菌活性。
