Division of Endocrinology, Metabolism, and Diabetes, University of Colorado, Anschutz Medical Campus, School of Medicine, Denver, Colorado, USA.
Obesity (Silver Spring). 2012 Nov;20(11):2186-93. doi: 10.1038/oby.2012.103. Epub 2012 Apr 23.
Despite living in an environment that promotes weight gain in many individuals, some individuals maintain a thin phenotype while self-reporting expending little or no effort to control their weight. When compared with obesity prone (OP) individuals, we wondered if obesity resistant (OR) individuals would have higher levels of spontaneous physical activity (SPA) or respond to short-term overfeeding by increasing their level of SPA in a manner that could potentially limit future weight gain. SPA was measured in 55 subjects (23 OP and 32 OR) using a novel physical activity monitoring system (PAMS) that measured body position and movement while subjects were awake for 6 days, either in a controlled eucaloric condition or during 3 days of overfeeding (1.4 × basal energy) and for the subsequent 3 days (ad libitum recovery period). Pedometers were also used before and during use of the PAMS to provide an independent measure of SPA. SPA was quantified by the PAMS as fraction of recording time spent lying, sitting, or in an upright posture. Accelerometry, measured while subjects were in an upright posture, was used to categorize time spent in different levels of movement (standing, walking slowly, quickly, etc.). There were no differences in SPA between groups when examined across all study periods (P > 0.05). However, 3 days following overfeeding, OP subjects significantly decreased the amount of time they spent walking (-2.0% of time, P = 0.03), whereas OR subjects maintained their walking (+0.2%, P > 0.05). The principle findings of this study are that increased levels of SPA either during eucaloric feeding or following short term overfeeding likely do not significantly contribute to obesity resistance although a decrease in SPA following overfeeding may contribute to future weight gain in individuals prone to obesity.
尽管生活在一个促进许多人体重增加的环境中，但有些人保持着消瘦的体型，同时自我报告说几乎没有或根本没有努力控制体重。与肥胖易感（OP）个体相比，我们想知道肥胖抵抗（OR）个体是否会有更高水平的自发性体力活动（SPA），或者是否会通过增加 SPA 水平来应对短期过食，从而有可能限制未来的体重增加。在 55 名受试者（23 名 OP 和 32 名 OR）中，使用一种新型的体力活动监测系统（PAMS）测量 SPA，该系统在受试者清醒状态下测量身体位置和运动，持续 6 天，要么处于热量控制状态，要么在 3 天的过食期（基础能量的 1.4 倍），随后的 3 天为自由恢复期。在使用 PAMS 之前和期间，还使用计步器提供 SPA 的独立测量。SPA 通过 PAMS 量化为记录时间中躺着、坐着或直立姿势的分数。当受试者处于直立姿势时，加速度计用于分类不同运动水平（站立、缓慢行走、快速行走等）所花费的时间。在所有研究期间，两组之间的 SPA 没有差异（P > 0.05）。然而，在过食后 3 天，OP 受试者显著减少了他们行走的时间（-2.0%的时间，P = 0.03），而 OR 受试者则保持了他们的行走时间（+0.2%，P > 0.05）。这项研究的主要发现是，无论是在热量控制喂养期间还是在短期过食后增加 SPA 水平，都不太可能显著有助于肥胖抵抗，尽管过食后 SPA 的减少可能会导致肥胖易感个体未来体重增加。
