Cerovec Mislav, Anić Branimir, Padjen Ivan, Cikes Nada
Mislav Cerovec, Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, University of Zagreb School of Medicine, University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia.
Croat Med J. 2012 Apr;53(2):149-54. doi: 10.3325/cmj.2012.53.149.
To identify systemic lupus erythematosus (SLE) patients diagnosed and treated at the outpatient clinic of our Division fulfilling at least four American College of Rheumatology (ACR) classification criteria at the time of the study, to determine the prevalence of each of the criteria at three different time points, and to compare the data with similar studies.
We performed retrospective and descriptive analysis of medical records of 162 patients fulfilling at least 4 ACR criteria. Classification criteria were counted and the frequency of each criterion was identified at three different time points: disease onset, time of diagnosis, and the time when the study was conducted.
At diagnosis and at the time when the study was conducted there were 3.8 and 5.4 fulfilled classification criteria, respectively. The most common criterion at the time of the disease onset was arthritis (52.6%); at the time of diagnosis it was positive antinuclear antibody (ANA) titer (88.0%); and at the time when the study was conducted it was positive ANA titer (95.7%), immunologic disorder (89.5%), arthritis (71.0%), hematologic disorder (70.4%), malar rash (61.7%), and photosensitivity (51.9%).
The prevalence of ACR criteria in our patients is similar to that in other studies, especially those involving Caucasian patients. Our results confirm the value of the ACR criteria in patients with an already established diagnosis. This is the first study on the prevalence of disease manifestations among Croatian patients with SLE.
确定在我们科室门诊诊断和治疗的系统性红斑狼疮（SLE）患者，这些患者在研究时至少符合四项美国风湿病学会（ACR）分类标准，确定三项不同时间点各标准的患病率，并将数据与类似研究进行比较。
我们对162例至少符合4项ACR标准的患者的病历进行回顾性和描述性分析。统计分类标准，并确定三项不同时间点各标准的频率：疾病发作时、诊断时以及进行研究时。
在诊断时和进行研究时，分别有3.8项和5.4项符合分类标准。疾病发作时最常见的标准是关节炎（52.6%）；诊断时是抗核抗体（ANA）滴度阳性（88.0%）；进行研究时是ANA滴度阳性（95.7%）、免疫紊乱（89.5%）、关节炎（71.0%）、血液系统紊乱（70.4%）、颊部红斑（61.7%）和光过敏（51.9%）。
我们患者中ACR标准的患病率与其他研究相似，尤其是那些涉及白种人患者的研究。我们的结果证实了ACR标准在已确诊患者中的价值。这是第一项关于克罗地亚SLE患者疾病表现患病率的研究。
