Snow B J, Tsui J K, Bhatt M H, Varelas M, Hashimoto S A, Calne D B
Belzberg Laboratory of Clinical Neuroscience, University of British Columbia, Vancouver, Canada.
Ann Neurol. 1990 Oct;28(4):512-5. doi: 10.1002/ana.410280407.
We studied the effect of botulinum-A toxin on spasticity of the leg adductors in 9 patients who were either chair-bound or bed-bound with chronic stable multiple sclerosis. We injected botulinum toxin (400 mouse units) or placebo into the adductor muscles in a randomized, crossover, double-blind design. Two physicians, who were unaware of the treatment order, used an objective rating scale and independently assessed the patients; interobserver correlation was excellent (r = 0.93-0.81). We found that botulinum toxin produced a significant reduction in spasticity (p = 0.009) and a significant improvement in the ease of nursing care (p = 0.009). There were no adverse effects during this short-term trial. This is the first demonstration of the beneficial effect of botulinum toxin on focal spastic muscle contractions.
我们研究了A型肉毒杆菌毒素对9例因慢性稳定型多发性硬化症而需坐轮椅或卧床的患者腿部内收肌痉挛的影响。我们采用随机、交叉、双盲设计，向这些患者的内收肌注射肉毒杆菌毒素（400鼠单位）或安慰剂。两位不知治疗顺序的医生使用客观评分量表对患者进行独立评估；观察者间的相关性极佳（r = 0.93 - 0.81）。我们发现肉毒杆菌毒素使痉挛显著减轻（p = 0.009），并使护理的便捷性显著改善（p = 0.009）。在这项短期试验中未出现不良反应。这是首次证明肉毒杆菌毒素对局灶性痉挛性肌肉收缩具有有益作用。
