The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, 195 Little Albany St., New Brunswick, NJ 08903, USA.
Cancer Causes Control. 2012 Jun;23(6):887-95. doi: 10.1007/s10552-012-9958-1. Epub 2012 Apr 19.
We evaluated the role of total dietary antioxidant capacity and of individual antioxidants on endometrial cancer risk in a population-based case-control study in New Jersey, including 417 cases and 395 controls. Dietary intake was ascertained using a food-frequency questionnaire (FFQ), and total antioxidant capacity (TAC) intake was estimated using the USDA Oxygen Radical Absorbance Capacity (ORAC) database and the University of Oslo's Antioxidant Food Database (AFD) and FFQ-derived estimates of intake. Odds ratios and 95 % confidence intervals were derived using multivariate logistic regression controlling for major endometrial cancer risk factors. Using the ORAC database, after adjusting for major covariates, we found decreased risks for the highest tertile of total phenolic intake compared with the lowest (OR: 0.62; 95 % CI: 0.39-0.98). There was no association for TAC intake based on the AFD, which utilized the ferric-reducing ability of plasma (FRAP) assay to assess antioxidant capacity. There was no strong evidence for an association with intake of any of the individual antioxidants. Our findings suggest that total phenolic consumption may decrease endometrial cancer risk.
我们在新泽西州进行了一项基于人群的病例对照研究，评估了总膳食抗氧化能力和个别抗氧化剂在子宫内膜癌风险中的作用，该研究纳入了 417 例病例和 395 例对照。膳食摄入量通过食物频率问卷（FFQ）确定，总抗氧化能力（TAC）摄入量则使用美国农业部的氧自由基吸收能力（ORAC）数据库、奥斯陆大学的抗氧化食品数据库（AFD）和基于 FFQ 的摄入量估计值进行估算。使用多元逻辑回归控制主要子宫内膜癌风险因素，得出比值比（OR）和 95%置信区间（CI）。在调整主要协变量后，我们发现与最低酚摄入量 tertile 相比，总酚摄入量最高 tertile 的子宫内膜癌风险降低（OR：0.62；95%CI：0.39-0.98）。使用 AFD（利用血浆铁还原能力（FRAP）测定法评估抗氧化能力）的 TAC 摄入量与风险之间没有关联。摄入任何个别抗氧化剂与风险之间也没有明显的关联。我们的研究结果表明，总酚类物质的消耗可能会降低子宫内膜癌的风险。
