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Molecules. 2010 Oct 21;15(10):7313-52. doi: 10.3390/molecules15107313.
Phenolics are broadly distributed in the plant kingdom and are the most abundant secondary metabolites of plants. Plant polyphenols have drawn increasing attention due to their potent antioxidant properties and their marked effects in the prevention of various oxidative stress associated diseases such as cancer. In the last few years, the identification and development of phenolic compounds or extracts from different plants has become a major area of health- and medical-related research. This review provides an updated and comprehensive overview on phenolic extraction, purification, analysis and quantification as well as their antioxidant properties. Furthermore, the anticancer effects of phenolics in-vitro and in-vivo animal models are viewed, including recent human intervention studies. Finally, possible mechanisms of action involving antioxidant and pro-oxidant activity as well as interference with cellular functions are discussed.
酚类广泛分布于植物界，是植物中最丰富的次生代谢物。由于其强大的抗氧化特性以及在预防各种与氧化应激相关的疾病（如癌症）方面的显著作用，植物多酚引起了越来越多的关注。在过去的几年中，从不同植物中鉴定和开发酚类化合物或提取物已成为健康和医学相关研究的主要领域。本综述提供了关于酚类化合物的提取、纯化、分析和定量及其抗氧化特性的最新和全面的概述。此外，还观察了酚类化合物在体外和体内动物模型中的抗癌作用，包括最近的人体干预研究。最后，讨论了涉及抗氧化和促氧化活性以及干扰细胞功能的可能作用机制。
