Rossi Marta, Tavani Alessandra, Ciociola Valentina, Ferraroni Monica, Parpinel Maria, Serafini Mauro, Bellocco Rino, Zucchetto Antonella, Montella Maurizio, Serraino Diego, Lagiou Pagona, La Vecchia Carlo
Department of Epidemiology, IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri", Via Giuseppe La Masa 19, 20156, Milan, Italy.
Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Via G. Venezian 1, 20133, Milan, Italy.
Cancer Causes Control. 2016 Mar;27(3):425-31. doi: 10.1007/s10552-016-0719-4. Epub 2016 Feb 1.
To investigate the role of the overall antioxidant activity of diet, we estimated the relation between three dietary indices of total antioxidant capacity (TAC) and endometrial cancer risk
We analyzed data from an Italian case-control study including 454 women with incident, histologically confirmed endometrial cancer, and 908 frequency-matched controls admitted to the same hospitals as cases for acute non-neoplastic conditions. A reproducible and valid food frequency questionnaire was used to assess subjects' habitual diet. TAC was measured using Italian food composition tables in terms of Ferric-reducing antioxidant power (FRAP), Trolox equivalent antioxidant capacity (TEAC), and total radical-trapping antioxidant parameter (TRAP). We computed odds ratios (OR) and corresponding 95 % confidence intervals (CIs) using conditional multiple logistic regression models, including terms for recognized endometrial cancer risk factors and total energy intake.
TAC was inversely related to endometrial cancer risk with ORs for the highest versus the lowest quartile of 0.69 (95 % CI 0.47-1.00) for FRAP, 0.68 (95 % CI 0.46-0.99) for TEAC, and 0.68 (95 % CI 0.47-0.98) for TRAP. The relations appeared consistent in strata of selected risk factors and decreased when considering TAC without the contribution of coffee.
Our findings suggest a favorable role of a diet high in TAC on endometrial cancer risk, which can be partially driven by coffee consumption.
为研究饮食的总体抗氧化活性的作用，我们评估了三种总抗氧化能力（TAC）饮食指数与子宫内膜癌风险之间的关系。
我们分析了一项意大利病例对照研究的数据，该研究包括454例经组织学确诊的新发子宫内膜癌女性患者，以及908例频率匹配的对照，这些对照因急性非肿瘤性疾病与病例在同一医院就诊。使用一份可重复且有效的食物频率问卷来评估受试者的习惯性饮食。根据意大利食物成分表，采用铁还原抗氧化能力（FRAP）、Trolox等效抗氧化能力（TEAC）和总自由基捕获抗氧化参数（TRAP）来测量TAC。我们使用条件多因素逻辑回归模型计算比值比（OR）和相应的95%置信区间（CI），模型中纳入了公认的子宫内膜癌风险因素和总能量摄入项。
TAC与子宫内膜癌风险呈负相关，FRAP最高四分位数与最低四分位数的OR为0.69（95%CI 0.47 - 1.00），TEAC为0.68（95%CI 0.46 - 0.99），TRAP为0.68（95%CI 0.47 - 0.98）。在选定风险因素的分层中，这种关系似乎一致，且在不考虑咖啡贡献的情况下计算TAC时，相关性降低。
我们的研究结果表明，高TAC饮食对子宫内膜癌风险具有有益作用，这可能部分由咖啡消费驱动。
