Council of Scientific and Industrial Research, Lucknow, India.
Mol Divers. 2012 May;16(2):335-50. doi: 10.1007/s11030-012-9369-y. Epub 2012 Apr 22.
Diversity-oriented synthesis of structurally different, novel and small drug like molecules based on 1,4,5-trisubstituted 1,2,3-triazoles is developed in a streamlined sequence of different sets of reactions. The method involves the use of simple, readily available and highly economical substrates and reagents. The molecules developed herein have potential to be exploited either as chemotherapeutic agents or as scaffolds for other biologically active compounds.
基于 1,4,5-三取代 1,2,3-三唑的结构不同、新颖且具有类药性的小分子的多样性导向合成，是在不同反应组合的简化序列中开发的。该方法涉及使用简单、易得且经济高效的底物和试剂。本文所开发的分子具有作为化疗药物或其他生物活性化合物骨架的潜力。
