胚胎干细胞分化中的神经酰胺和1-磷酸鞘氨醇信号传导
Ceramide and sphingosine-1-phosphate signaling in embryonic stem cell differentiation.
作者信息
Bieberich Erhard
机构信息
Program in Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA, USA.
出版信息
Methods Mol Biol. 2012;874:177-92. doi: 10.1007/978-1-61779-800-9_14.
Abstract
Recent studies show that bioactive lipids are important regulators for stem cell survival and differentiation. The sphingolipid ceramide and its derivative, sphingosine-1-phosphate (S1P), can act synergistically on embryonic stem (ES) cell differentiation. We show here simple methods to analyze sphingolipids in differentiating ES cells and to use ceramide and S1P analogs for the guided differentiation of mouse ES cells toward neuronal and glial lineage.
摘要
最近的研究表明，生物活性脂质是干细胞存活和分化的重要调节因子。鞘脂神经酰胺及其衍生物鞘氨醇-1-磷酸（S1P）可协同作用于胚胎干细胞（ES细胞）的分化。我们在此展示了分析分化中的ES细胞中鞘脂的简单方法，以及使用神经酰胺和S1P类似物来引导小鼠ES细胞向神经元和神经胶质谱系分化的方法。
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