Division of Emergency Medicine, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
J Med Toxicol. 2012 Sep;8(3):263-6. doi: 10.1007/s13181-012-0227-1.
Infant and toddler poisonings are important to capture and may be challenging to manage. We aim to describe the Toxicology Investigators Consortium (ToxIC) Case Registry as a tool for toxico-surveillance of this problem in the United States. Using the ToxIC Case Registry database of the American College of Medical Toxicology, we identified infant and toddler poisonings over a 15-month period between April 1, 2010 and June 30, 2011 reported to the 31 Registry sites. Of 6,810 poisoning cases reported to the ToxIC registry, 248 (3.6 %) involved children younger than 2 years (51 % males). Fifty-four percent were hospital inpatients, 42 % were in the Emergency Department and 4 % were outpatients. Sixty-three percent were symptomatic. The most common ingested compounds were highly toxic-cardiac drugs (16 %), psychotropics (15 %), recreational drugs, alcohols, and controlled narcotic drugs (13 %), analgesics (9 %), and cleaning compounds (7 %). Fourteen percent of cases involved multiple agents. The ToxIC registry is a potentially useful toxico-surveillance tool to identify and trend clinically significant poisonings in young children, and potentially other populations. These data could be used to target specific preventive interventions.
婴幼儿中毒是需要重点关注的问题，且其管理可能具有挑战性。我们旨在将毒理学家联合会（ToxIC）病例登记处描述为一种用于毒理学监测美国此类问题的工具。利用美国医学毒理学学院毒理学家联合会病例登记处数据库，我们在美国 31 个登记处报告的 2010 年 4 月 1 日至 2011 年 6 月 30 日期间的 15 个月内，发现了 6810 例婴幼儿中毒报告。在向毒理学家联合会登记处报告的 6810 例中毒病例中，有 248 例（3.6%）涉及 2 岁以下儿童（51%为男性）。54%为住院患者，42%在急诊室，4%为门诊患者。63%的患者有症状。最常见的摄入化合物是毒性很强的心脏药物（16%）、精神药物（15%）、娱乐性药物、酒精和受控麻醉药物（13%）、止痛药（9%）和清洁剂（7%）。14%的病例涉及多种药物。ToxIC 登记处是一种潜在有用的毒理学监测工具，可用于识别和跟踪幼儿以及其他人群中具有临床意义的中毒事件。这些数据可用于有针对性地开展特定的预防干预措施。
