Department of Emergency Medicine, Division of Medical Toxicology, University of Southern California, 1200 N State St. Rm 1011, Los Angeles, CA, 90033, USA.
Hartford Hospital and University of Connecticut School of Medicine, 80 Seymour Street, Hartford, CT, 06102, USA.
J Med Toxicol. 2019 Oct;15(4):228-254. doi: 10.1007/s13181-019-00736-9. Epub 2019 Oct 22.
The Toxicology Investigators Consortium (ToxIC) Registry was established by the American College of Medical Toxicology (ACMT) in 2010. The Registry collects data from participating sites with the agreement that all bedside medical toxicology consultation will be entered. The objective of this ninth annual report is to summarize the Registry's 2018 data and activity with its additional 7043 cases. Cases were identified for inclusion in this report by a query of the ToxIC database for any case entered from 1 January to 31 December 2018. Detailed data was collected from these cases and aggregated to provide information which included demographics, reason for medical toxicology evaluation, agent and agent class, clinical signs and symptoms, treatments and antidotes administered, mortality, and whether life support was withdrawn. A total of 51.5% of cases were female, 48% were male, and 0.6% transgender. Non-opioid analgesics were the most commonly reported agent class, followed by antidepressants and opioids. Acetaminophen was once again the most common agent reported. There were 106 fatalities, comprising 1.5% of all registry cases. Major trends in demographics and exposure characteristics remained similar to past years' reports. Sub-analyses were conducted to describe exposures in elderly patients, addiction consultation practices, and risk factors for bupropion-induced seizures. The launch of the ToxIC Qualified Clinical Data Registry (TQCDR) is also described.
毒理学调查人员联合会（ToxIC）注册中心由美国医学毒理学学院（ACMT）于 2010 年成立。该注册中心从参与机构收集数据，协议规定所有床边医疗毒理学咨询都将被录入。本第九年度报告的目的是总结该注册中心 2018 年的数据和活动，以及另外 7043 例病例。本报告中的病例是通过对 ToxIC 数据库进行查询确定的，这些病例是在 2018 年 1 月 1 日至 12 月 31 日期间录入的。从这些病例中收集了详细数据并进行了汇总，以提供包括人口统计学、医疗毒理学评估的原因、药物和药物类别、临床体征和症状、治疗和解毒剂的使用、死亡率以及是否撤掉生命支持的信息。女性病例占 51.5%，男性病例占 48%，跨性别者占 0.6%。非阿片类镇痛药是报告最常见的药物类别，其次是抗抑郁药和阿片类药物。对乙酰氨基酚再次成为报告最常见的药物。有 106 例死亡病例，占总病例的 1.5%。人口统计学和暴露特征的主要趋势与过去几年的报告相似。进行了亚分析以描述老年患者的暴露情况、成瘾咨询实践以及与安非他酮引起的癫痫发作相关的风险因素。还介绍了 ToxIC 合格临床数据注册中心（TQCDR）的启动情况。
