Svane D, Lundin S, Andersson K E, Forman A
Department of Obstetrics and Gynecology, University of Aarhus, Denmark.
Br J Obstet Gynaecol. 1990 Nov;97(11):1033-7. doi: 10.1111/j.1471-0528.1990.tb02478.x.
Tissue specimens from the fundus, isthmus and distal cervix were obtained from 14 women at hysterectomy at various phases of the menstrual cycle. Ring preparations of small intramyometrial and intracervical arteries were dissected and mounted in organ baths; isometric tension was recorded and responses to contractile agents were studied. The amplitude of responses to K+ (124 mmol/l) of the vessel preparations ranked fundus greater than or equal to isthmus greater than cervix. While similar pD2 values for noradrenaline (NA) were found, the Emax values ranked cervix greater than or equal to isthmus greater than or equal to fundus (cervix greater than fundus). The pD2 values for arginine-vasopressin (AVP) showed minor differences, while the Emax values for this peptide ranked fundus greater than or equal to isthmus greater than or equal to cervix (fundus greater than cervix). Arteries from the fundus and isthmus displayed weak, inconsistent contractile responses to prostaglandin F2 alpha, but more pronounced contractions were induced by this prostanoid in arterial preparations from the distal cervix. The results suggest regional differences in vascular mechanical responses to endogenous vasoactive agents in the human uterus.
在月经周期的不同阶段，从14名接受子宫切除术的女性身上获取了来自子宫底部、峡部和宫颈远端的组织标本。解剖并将子宫肌层内小动脉和宫颈内动脉的环行标本安装在器官浴槽中；记录等长张力，并研究对收缩剂的反应。血管标本对K⁺（124 mmol/L）反应的幅度排序为：子宫底部≥峡部＞宫颈。虽然去甲肾上腺素（NA）的pD2值相似，但最大效应（Emax）值排序为：宫颈≥峡部≥子宫底部（宫颈＞子宫底部）。精氨酸加压素（AVP）的pD2值差异较小，而该肽的Emax值排序为：子宫底部≥峡部≥宫颈（子宫底部＞宫颈）。子宫底部和峡部的动脉对前列腺素F2α表现出微弱、不一致的收缩反应，但该类前列腺素在宫颈远端的动脉标本中诱导出更明显的收缩。结果表明，人类子宫内血管对内源性血管活性物质的机械反应存在区域差异。
