Department of Anaesthesiology, Kasturba Medical College, Mangalore, India.
Indian J Pharmacol. 2012 Mar;44(2):193-6. doi: 10.4103/0253-7613.93847.
Hypotension is a common complication of spinal anesthesia and is frequent in patients with hypertension. Antihypertensive agents decrease this effect by controlling blood pressure. There are conflicting reports on the continuation of antihypertensive drugs on the day of surgery in patients undergoing spinal anesthesia. Sudden hypotension could have detrimental effect on the organ systems. This study was undertaken to compare the variation in blood pressure in hypertensive patients on β-blockers and calcium channel blockers undergoing spinal anesthesia.
Ninety patients were enrolled for the study, 30 each in the control, β-blocker and the calcium channel blocker groups.
The incidence of hypotension was not different among the three groups. However, the number of times mephentermine used to treat hypotension was significant in the patients receiving calcium channel blockers while incidence of bradycardia in patients treated with β-blockers was significant (P<0.001).
The incidence of hypotension following spinal anesthesia is not different in patients receiving β-blockers and calcium channel blockers among the three groups.
低血压是椎管内麻醉的常见并发症，在高血压患者中更为常见。降压药通过控制血压来降低这种作用。关于在接受椎管内麻醉的患者中，手术当天继续使用降压药的问题存在相互矛盾的报道。突然的低血压可能对各器官系统产生不良影响。本研究旨在比较接受β受体阻滞剂和钙通道阻滞剂治疗的高血压患者在椎管内麻醉下血压的变化。
本研究共纳入 90 例患者，每组 30 例，分别为对照组、β受体阻滞剂组和钙通道阻滞剂组。
三组患者低血压的发生率无差异。然而，在接受钙通道阻滞剂治疗的患者中，使用美芬丁胺治疗低血压的次数显著增加，而接受β受体阻滞剂治疗的患者中心动过缓的发生率显著增加（P<0.001）。
在接受椎管内麻醉的患者中，β受体阻滞剂和钙通道阻滞剂组的低血压发生率无差异。
