Goel Ruchika, Danda Debashish, Mathew John, Chacko Ashok
Department of Clinical Immunology and Rheumatology, Christian Medical College & Hospital, Vellore-632004, Tamil Nadu, India.
Open Rheumatol J. 2012;6:21-3. doi: 10.2174/1874312901206010021. Epub 2012 Apr 11.
Pancreatitis in Systemic Lupus Erythematosus (SLE) is a rare, but life threatening complication. We aimed to study the characteristics and treatment outcome of SLE patients with acute pancreatitis in comparison with those with abdominal pain due to causes other than pancreatitis. Records of SLE patients admitted in our ward with pain abdomen between January 2008 and July 2010 were studied retrospectively. Of 551 SLE in-patients during the study period, 28 (5%) had abdominal pain and 11 (2%) of them were diagnosed to have acute pancreatitis. Five of the 11 patients had severe pancreatitis and 6 had mild pancreatitis. Seizures, arthritis and lack of prior use of steroids were significantly more common in patients with pancreatitis as compared to those with abdominal pain of non pancreatic origin. Seizure occurred more often in severe pancreatitis group as compared to mild pancreatitis. There was no difference in prevalence of lupus anticoagulant and anticardiolipin antibody (40%) between SLE patients with pancreatitis and those with other causes of abdominal pain.
Association of pancreatitis in our cohort of SLE patients include withdrawal of maintenance dose of steroids, seizures and arthritis in univariate analysis. However there was no independent predictor of this complication in our study.
系统性红斑狼疮（SLE）合并胰腺炎是一种罕见但危及生命的并发症。我们旨在研究SLE合并急性胰腺炎患者的特征及治疗结果，并与因非胰腺炎原因引起腹痛的患者进行比较。回顾性研究了2008年1月至2010年7月期间在我们病房因腹痛入院的SLE患者的记录。在研究期间的551例SLE住院患者中，28例（5%）有腹痛，其中11例（2%）被诊断为急性胰腺炎。11例患者中5例为重症胰腺炎，6例为轻症胰腺炎。与非胰腺源性腹痛患者相比，胰腺炎患者中癫痫发作、关节炎及未预先使用类固醇更为常见。与轻症胰腺炎相比，重症胰腺炎组癫痫发作更频繁。SLE合并胰腺炎患者与其他腹痛原因患者之间狼疮抗凝物和抗心磷脂抗体的患病率无差异（40%）。
在我们的SLE患者队列中，胰腺炎的相关因素在单因素分析中包括停用维持剂量的类固醇、癫痫发作和关节炎。然而，在我们的研究中没有该并发症的独立预测因素。
