Izon Science, Begbroke Science Park, Oxford, OX5 1PF, UK.
Future Med Chem. 2012 Apr;4(6):783-97. doi: 10.4155/fmc.12.26.
Resistance to commercially available antimalarial drugs is a public health problem. Since the end of the last century, no new antimalarial drugs have been introduced into clinical practice, and new drug development has been quite disappointing. There is therefore a real need to develop new class of antimalarial drugs that could be used alone or in combination. This review describes the development and recent advances on the preparation of ferrocenic compounds as a new class of antimalarial agents with potential for clinical development.
抗药性是一个公共卫生问题。自上世纪末以来，没有新的抗疟药物被引入临床实践，新药研发也相当令人失望。因此，确实需要开发新的抗疟药物类别，可以单独使用或联合使用。本综述描述了铁芳基化合物作为一类新的抗疟药物的开发和最近进展，具有临床开发的潜力。
