Université Lille 1, Unité de Glycobiologie Structurale et Fonctionnelle, 59650 Villeneuve d'Ascq, France.
Dalton Trans. 2012 Jun 7;41(21):6335-49. doi: 10.1039/c2dt12247b. Epub 2012 Feb 24.
Despite recent encouraging advances against the disease, malaria remains a major public health problem affecting almost half a billion people and killing almost a million per annum. Due to a short arsenal of efficient antimalarial agents and the frequent appearance of resistance to the drugs in current use, which consequently reduce our means to treat patients, there is a very urgent and continuous need to develop new compounds. This perspective outlines a unique strategy for that purpose through the development of metal-based antimalarial agents. The examples presented here illustrate an attractive alternative to classical drugs.
尽管最近在对抗这种疾病方面取得了令人鼓舞的进展，但疟疾仍然是一个主要的公共卫生问题，影响着近 5 亿人，每年导致近 100 万人死亡。由于有效的抗疟药物储备有限，而且目前使用的药物经常出现耐药性，这反过来又降低了我们治疗患者的手段，因此非常迫切和持续地需要开发新的化合物。本文通过开发基于金属的抗疟药物概述了实现这一目标的独特策略。这里提出的例子说明了一种有吸引力的替代传统药物的方法。
