Reeves B R, Nash R, Lawler S D, Fisher C, Treleaven J G, Wiltshaw E
Institute of Cancer Research, Chester Beatty Laboratories, London, England.
Cancer Genet Cytogenet. 1990 Nov 1;50(1):1-8. doi: 10.1016/0165-4608(90)90231-x.
A case of Hodgkin's disease is described in which cytogenetic studies were performed at intervals for 5 years. Clonally related chromosomally rearranged cells persisted during that time, with emergence of more complex karyotypes in the terminal phase of the disease. The chromosome findings are discussed in relation to the limited data available on banded karyotypes in Hodgkin's disease.
本文描述了一例霍奇金病患者，对其进行了为期5年的细胞遗传学定期研究。在此期间，克隆相关的染色体重排细胞持续存在，在疾病终末期出现了更复杂的核型。结合霍奇金病带型核型的有限数据对染色体研究结果进行了讨论。
