非霍奇金淋巴瘤患者骨髓和血细胞中非随机染色体畸变的研究。
Study of nonrandom chromosome aberrations in bone marrow and blood cells of patients with non-Hodgkin's lymphomas.
作者信息
Ankina M A, Pavlov V V, Shakhtarina S V, Panfyorova T A, Zavitaeva T A, Danilenko A A
机构信息
Department of Cellular and Experimental Radiotherapy, Medical Radiology Center, Russian Academy of Medical Sciences, Obninsk, Russia.
出版信息
Bull Exp Biol Med. 2010 Oct;149(5):621-4. doi: 10.1007/s10517-010-1008-y.
PMID:21165402
Abstract
Complete karyotyping of G-stained chromosomes of bone marrow and blood cells was carried out in patients with non-Hodgkin's lymphomas before and after antitumor therapy, in remissions and relapses. Clones with 1q41-43, 2q35, and 6q24-27 deletions were most incident. Their incidence in patients increased after antitumor therapy.
摘要
在接受抗肿瘤治疗之前和之后、缓解期和复发期的非霍奇金淋巴瘤患者中，对骨髓和血细胞的G显带染色体进行了完整的核型分析。1q41 - 43、2q35和6q24 - 27缺失的克隆最为常见。抗肿瘤治疗后患者中这些克隆的发生率增加。
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