Lawler S D, Summersgill B M, McElwain T J
Cancer Genet Cytogenet. 1982 Feb;5(1):25-35. doi: 10.1016/0165-4608(82)90038-3.
A cytogenetic study was made of bone marrow cells and lymphocytes from patients who had been successfully treated with various regimens for Hodgkin's disease. Most of the patients had been off treatment for at least 3 years before the study began. They were divided into three groups according to the intensity of the therapy received. The frequency of gaps and breaks in the chromosomes of lymphocytes was above normal limits and similar in the three treatment groups. In contrast, the frequency of both lymphocytes and bone marrow cells with rearranged karyotypes was correlated with the intensity of treatment. Clones of cells with an abnormal karyotype were found in only two patients, both of whom were in the group receiving the most intensive therapy, i.e., chemotherapy and total nodal irradiation.
对曾用各种方案成功治疗过霍奇金病的患者的骨髓细胞和淋巴细胞进行了细胞遗传学研究。大多数患者在研究开始前至少已停止治疗3年。根据接受治疗的强度将他们分为三组。淋巴细胞染色体中裂隙和断裂的频率高于正常范围，且在三个治疗组中相似。相比之下，核型重排的淋巴细胞和骨髓细胞的频率与治疗强度相关。仅在两名患者中发现了核型异常的细胞克隆，这两名患者均在接受最强化治疗的组中，即化疗和全淋巴结照射组。
