Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Box 97, Houston, TX 77030, USA.
Curr Oncol Rep. 2012 Aug;14(4):320-6. doi: 10.1007/s11912-012-0235-y.
Pediatric sarcoma includes a diverse group of pathologies classified, based on the cell of origin, as primary bone or soft tissue sarcomas. Radiotherapy plays an integral role in the multidisciplinary approach required for optimal therapy in these patients. The particular challenges faced by the radiation oncologist while treating these patients include the age of the patient and the location of these tumors, as they are very often adjacent to critical or growing organs. Technical advances in radiation oncology, including highly conformal planning and improved tumor delineation, may allow a reduction in radiation related toxicities with excellent tumor control. In this chapter, the role of radiotherapy will be reviewed as well as modern technologies that are currently available and under development, with an emphasis on the application of these strategies in the pediatric and young adult population.
儿科肉瘤包括一组不同的病理学，根据起源细胞的不同，可分为原发性骨或软组织肉瘤。放射治疗在为这些患者提供最佳治疗的多学科方法中发挥着不可或缺的作用。放射肿瘤学家在治疗这些患者时面临的特殊挑战包括患者的年龄和这些肿瘤的位置，因为它们通常紧邻关键或生长中的器官。放射肿瘤学方面的技术进步，包括高度适形规划和肿瘤勾画的改善，可能会减少与放射相关的毒性，同时实现出色的肿瘤控制。本章将回顾放射治疗的作用，以及目前可用和正在开发的现代技术，重点介绍这些策略在儿科和青年人群中的应用。
