Department of Periodontology, Faculty of Odontology, Complutense University of Madrid, Madrid, Spain.
J Clin Periodontol. 2012 Feb;39 Suppl 12:6-27. doi: 10.1111/j.1600-051X.2011.01830.x.
The aim was to assess the quality of reporting of experimental research in implant dentistry by a critical evaluation of study design, outcome assessments and model validation.
MATERIAL & METHODS: An online search was performed using the MEDLINE. Experimental studies performed in both animals and humans were included. A’stratified random sample of the included studies was extracted and used for quantitative and qualitative analyses. Modified versions of the ARRIVE guidelines were used for quality assessment.
A total of 982 papers were eligible and used for quantitative analyses. A’stratified random sample of 193 publications was extracted. The dog model was the most used experimental model whereas experimental studies on humans were few. Intra-oral experimental sites dominated in human, monkey, dog and mini-pig studies. Extra oral sites dominated in rabbit, rodent and goat/sheep studies. Studies on the pathogenesis and treatment of peri-implant diseases were few.
Different animal models, experimental protocols and methods of analysis have been used to address different areas of experimental research in implant dentistry. Standardized designs for investigations within this type of experimental research seem to be lacking. Furthermore, in many of these studies there were limitations in reporting on methodology and statistical methods.
通过对研究设计、结果评估和模型验证的严格评估，评估口腔种植学中实验研究的报告质量。
使用 MEDLINE 进行在线检索，纳入动物和人类实验研究。提取纳入研究的分层随机样本，进行定量和定性分析。使用改良版 ARRIVE 指南进行质量评估。
共纳入 982 篇论文进行定量分析，提取了 193 篇出版物的分层随机样本。狗模型是最常用的实验模型，而关于人类的实验研究较少。口腔内实验部位在人类、猴子、狗和迷你猪研究中占主导地位。口腔外部位在兔、啮齿动物和山羊/绵羊研究中占主导地位。关于种植体周围疾病发病机制和治疗的研究较少。
不同的动物模型、实验方案和分析方法已用于解决口腔种植学中不同领域的实验研究。此类实验研究中似乎缺乏标准化的研究设计。此外，在这些研究中的许多研究中，在方法学和统计方法的报告方面存在局限性。
