Clinic of Cranio-Maxillofacial and Oral Surgery, University of Zurich, Zurich, Switzerland.
J Clin Periodontol. 2012 Feb;39 Suppl 12:28-36. doi: 10.1111/j.1600-051X.2011.01835.x.
The aim of this systematic review was to assess the scientific literature in terms of pre-clinical studies evaluating the influence of material, surface and design on the integration of an implant by hard and soft tissues. The included publications were analysed with regard to the frequency of reporting of criteria being derived from the ARRIVE guidelines. This served to trace elements within animal studies, where the quality of reporting needs to improve.
The literature search was performed in Ovid Medline and included English literature from January 1990 to July 2011. A list of 24 criteria derived from the ARRIVE guidelines for animal research was adjusted to implant studies on osseointegration in pristine bone and was applied to all included study manuscripts. Each criteria was graded by "0" (not reported) or "1" (reported) and the frequency of reporting for each criteria was recorded.
A total of 271 studies were included into this review. Generally the quality of reporting increased with time. Low frequencies of reporting were achieved for criteria like "randomisation of animals", "reasons for the animal model" and "relevance to humans".
The frequency of reporting showed high percentages for most criteria. However, the quality of reporting in pre-clinical studies needs to improve in areas like the reporting of statistical information, study setup and the possible translation of the results to humans.
本系统评价旨在评估评估材料、表面和设计对植入物软硬组织整合影响的临床前研究文献。分析了纳入文献中源自 ARRIVE 指南的标准报告频率。这有助于追踪动物研究中的要素，这些研究需要提高报告质量。
文献检索在 Ovid Medline 进行，纳入了 1990 年 1 月至 2011 年 7 月的英文文献。根据 ARRIVE 指南，为骨整合的种植体研究调整了 24 个标准列表，应用于所有纳入的研究论文。每个标准的评分为“0”（未报告）或“1”（报告），并记录每个标准的报告频率。
共有 271 项研究纳入本综述。报告质量通常随着时间的推移而提高。动物随机分组、动物模型的原因和与人类的相关性等标准的报告频率较低。
大多数标准的报告频率较高。然而，临床前研究的报告质量需要在统计信息报告、研究设计和结果向人类的可能转化等方面得到提高。
