Utrabo Carlos Alberto Lima, Czeczko Nicolau Gregori, Busato Cesar Roberto, Montemor-Netto Mario Rodrigues, Malafaia Osvaldo, Dietz Ulrich Andreas
School of Medicine, State University of Ponta Grossa, PR, Brazil.
Acta Cir Bras. 2012 Apr;27(4):300-5. doi: 10.1590/s0102-86502012000400004.
To evaluate the healing process of a defect in the ventral abdominal wall of rats, comparing the polypropylene and polypropylene/poliglecaprone meshes on the 30(th) and 60(th) postoperative day.
Thirty two Wistar rats were submitted to a ventral abdominal wall defect, with integrity of the parietal peritoneum. In the repair, were used polypropylene (group A) and polypropylene/poliglecaprone (group B) meshes. The groups were subdivided into four subgroups of eight animals euthanized on the 30(th) (A30 and B30) and 60(th) postoperative day (A60 and B60). Fragments of the abdominal wall of the animals were submitted to macroscopic, tensiometric and histological evaluations.
The tensiometry on subgroup A30 showed a mean average break point of 0.78 MPa and in A60, 0.66 Mpa. In subgroup B30 it was 0.84 MPa and in B60, 1.27 Mpa. The score of the inflammatory process showed subacute phase on A30 and B30 sub-groups and chronic inflammatory process in subgroups A30 and 60B.
The tensile strength was higher on the wall repaired by polypropylene/poliglecaprone mesh in the 60(th) post-operative day. Histology showed higher concentration of fibrosis on the surface of the polypropylene mesh with a tendency to encapsulation. In polypropylene/poliglecaprone subgroups the histology showed higher concentration of fibrosis on the surface of mesh filaments.
评估大鼠腹前壁缺损的愈合过程，比较术后第30天和第60天时聚丙烯网片和聚丙烯/聚乙交酯丙交酯网片的情况。
32只Wistar大鼠造成腹前壁缺损，壁腹膜完整。修复时使用聚丙烯网片（A组）和聚丙烯/聚乙交酯丙交酯网片（B组）。每组再分为四个亚组，每组8只动物，分别在术后第30天（A30和B30）和第60天（A60和B60）安乐死。对动物的腹壁组织进行宏观、张力测定和组织学评估。
A30亚组的张力测定平均断裂点为0.78兆帕，A60亚组为0.66兆帕。B30亚组为0.84兆帕，B60亚组为1.27兆帕。炎症过程评分显示，A30和B30亚组处于亚急性期，A60和B60亚组处于慢性炎症期。
术后第60天，用聚丙烯/聚乙交酯丙交酯网片修复的腹壁抗拉强度更高。组织学显示，聚丙烯网片表面纤维化浓度较高，有形成包膜的趋势。在聚丙烯/聚乙交酯丙交酯亚组中，组织学显示网丝表面纤维化浓度较高。
