Serour F, Dan M, Gorea A, Gilad A, Krispin M, Berger S A
Department of Surgery A, E. Wolfson Medical Center, Holon.
Chemotherapy. 1990;36(4):251-3. doi: 10.1159/000238774.
Each of 30 patients underwent elective laparotomy following administration of a single intravenous dose of amikacin, netilmicin or tobramycin. Therapeutic concentrations of amikacin were achieved in peritoneal tissue in 10/10 patients. Only 13/20 samples from patients receiving the other two antibiotics showed antibacterial activity. Our data suggest that the penetrability of tobramycin (53%) and amikacin (39%) into the uninflamed peritoneal tissue is superior to that of netilmicin (16%).
30名患者每人在静脉注射一剂阿米卡星、奈替米星或妥布霉素后接受了择期剖腹手术。10名接受阿米卡星治疗的患者的腹膜组织中达到了治疗浓度。接受其他两种抗生素治疗的患者的20份样本中只有13份显示出抗菌活性。我们的数据表明，妥布霉素（53%）和阿米卡星（39%）进入未发炎腹膜组织的渗透性优于奈替米星（16%）。
