Woo F L, Johnson A P, Insler M S, George W J, LaCorte W S
Arch Ophthalmol. 1985 Feb;103(2):216-8. doi: 10.1001/archopht.1985.01050020068022.
Peak and trough tear and serum concentrations were determined in 27 human volunteers undergoing intravenous (IV) gentamicin sulfate, tobramycin sulfate, amikacin sulfate, and netilmicin sulfate therapy. Although effective serum concentrations were achieved, tear levels were subtherapeutic. The mean peak tear concentrations were 0.4 microgram/mL, 0.5 microgram/mL, 1.7 micrograms/mL, and 0.3 microgram/mL for gentamicin, tobramycin, amikacin, and netilmicin, respectively. These levels did not approach the minimum inhibitory concentrations for Pseudomonas and raise some concern regarding the risk-benefit ratio of IV antibiotics for bacterial keratitis.
对27名接受硫酸庆大霉素、硫酸妥布霉素、硫酸阿米卡星和硫酸奈替米星静脉注射治疗的人类志愿者测定了泪液和血清的峰浓度及谷浓度。尽管达到了有效的血清浓度，但泪液中的浓度低于治疗水平。庆大霉素、妥布霉素、阿米卡星和奈替米星的平均泪液峰浓度分别为0.4微克/毫升、0.5微克/毫升、1.7微克/毫升和0.3微克/毫升。这些浓度未达到对铜绿假单胞菌的最低抑菌浓度，这引发了人们对静脉注射抗生素治疗细菌性角膜炎的风险效益比的一些担忧。
