Jacqz-Aigrain E, Wood C, Robieux I
Unité de Pharmacologie Clinique Hôpital Robert Debré, Paris, France.
Eur J Clin Pharmacol. 1990;39(2):191-2. doi: 10.1007/BF00280059.
Midazolam is a water soluble benzodiazepine, with a short elimination half-life in adults and children. An IV bolus of midazolam 0.2 mg.kg-1 was administered to 10 critically ill neonates receiving intensive care who required sedation. The plasma clearance was 6.85 ml.min-1 and the elimination half-life was 6.52 h. Midazolam was well tolerated during and after administration. Because of its short half-life compared to diazepam, midazolam could be used during the neonatal period to produce brief rapid sedation.
