Kirk S J, Cooper G G, Hoper M, Watt P C, Roy A D, Odling-Smee W
Department of Surgery, Queen's University, Belfast, Northern Ireland.
Eur J Surg Oncol. 1990 Dec;16(6):481-5.
Twenty-five patients with early breast cancer (T0-T2, N0-N1, M0) have been studied prospectively to determine the relationship between marrow micrometastases, disease-free interval and survival. Marrow specimens were aspirated from three sites immediately prior to breast surgery. An immunocytochemical technique using monoclonal antibody LICR.LON.M8.4 was employed to detect micrometastases. The minimum follow-up was 38 months. Twelve of the 25 patients (48%) had micrometastatic lesions in their marrow at presentation. Four of these patients developed distal recurrence during follow-up, causing death in two of them. Five of the 13 patients with no evidence of micrometastases developed distant recurrence and four of them have died. There was no correlation between the state of the marrow and the development of metastatic disease, although axillary lymph node status, disease stage and tumour volume correlated significantly with outcome (all P less than 0.025). Micrometastatic lesions appear to be common in the marrow of patients with early breast cancer. We have been unable to demonstrate that they have prognostic significance.
对25例早期乳腺癌（T0-T2，N0-N1，M0）患者进行了前瞻性研究，以确定骨髓微转移、无病间期和生存率之间的关系。在乳房手术前立即从三个部位抽取骨髓标本。采用使用单克隆抗体LICR.LON.M8.4的免疫细胞化学技术检测微转移。最短随访时间为38个月。25例患者中有12例（48%）在就诊时骨髓中有微转移病变。其中4例患者在随访期间发生远处复发，2例死亡。13例无微转移证据的患者中有5例发生远处复发，其中4例死亡。骨髓状态与转移性疾病的发生之间无相关性，尽管腋窝淋巴结状态、疾病分期和肿瘤体积与预后显著相关（所有P均小于0.025）。微转移病变在早期乳腺癌患者的骨髓中似乎很常见。我们未能证明它们具有预后意义。
