Department of Immunology, Monash University, Melbourne, Victoria 3004, Australia.
Peptides. 2012 Jul;36(1):142-50. doi: 10.1016/j.peptides.2012.04.008. Epub 2012 Apr 17.
In the present review we examine the experimental and clinical evidence for the presence of a local renin-angiotensin system within the retina. Interest in a pathogenic role for the renin-angiotensin system in retinal disease originally stemmed from observations that components of the pathway were elevated in retina during the development of certain retinal pathologies. Since then, our knowledge about the contribution of the RAS to retinal disease has greatly expanded. We discuss the known functions of the renin-angiotensin system in retinopathy of prematurity and diabetic retinopathy. This includes the promotion of retinal neovascularization, inflammation, oxidative stress and neuronal and glial dysfunction. The contribution of specific components of the renin-angiotensin system is evaluated with a particular focus on angiotensin II and aldosterone and their cognate receptors. The therapeutic utility of inhibiting key components of the renin-angiotensin system is complex, but may hold promise for the prevention and improvement of vision threatening diseases.
在本综述中，我们研究了视网膜内局部肾素-血管紧张素系统存在的实验和临床证据。人们对肾素-血管紧张素系统在视网膜疾病中的致病作用产生兴趣，最初源于这样的观察结果：在某些视网膜病变的发展过程中，该途径的成分在视网膜中升高。从那时起，我们对 RAS 对视网膜疾病的贡献的了解大大扩展了。我们讨论了肾素-血管紧张素系统在早产儿视网膜病变和糖尿病性视网膜病变中的已知功能。这包括促进视网膜新生血管形成、炎症、氧化应激以及神经元和神经胶质功能障碍。特别关注血管紧张素 II 和醛固酮及其同源受体，评估了肾素-血管紧张素系统的特定成分的贡献。抑制肾素-血管紧张素系统关键成分的治疗效用很复杂，但可能有希望预防和改善威胁视力的疾病。
