Luo Rui, Zhong Li-Li, Yi Hong-Ling, Tan Yu-Pin, Chen Min, Li Yun
Department of Pediatrics, First Affiliated Hospital of Hunan Normal University, Changsha, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2012 Apr;14(4):282-4.
To study the characteristics of allergic reactions to common aeroallergens in young children with wheezing or allergic diseases by examining the results of skin prick test in children under 5 years old.
A total of 196 children under 5 years old, from a district of Changsha City sampled between September 1 to December 31, 2010, were assigned into two groups according to the presence of wheezing or allergic diseases: allergen screening (n=102) and control (n=94). Skin prick tests were performed on both groups.
The positive rate of skin prick test in the allergen screening group was 61.8% (63/102), and this was significantly higher than in the control group (9.6%, 9/94; P<0.05). In the allergen screening group, the positive rate of skin prick test in children with both recurrent wheezing and allergic rhinitis was significantly higher than in children with wheezing alone (P<0.05). The frequency of wheezing was positively correlated with a positive skin prick test (r=0.91; P<0.05). The positive rate of skin prick test for mites was significantly higher than for other aeroallergens (24.2% vs 3.5%; P<0.05) in the allergen screening group. Skin prick testing of the children for dermatophagoides farinae showed a higher positive rate than for dermatophagoides pteronyssinus (50.0% vs 14.7%; P<0.05).
Wheezing in early childhood may be associated with the occurrence of asthma. Skin prick testing contributes to the diagnosis of allergic diseases and assessment of allergic reactions to aeroallergens in children with wheezing.
通过检测5岁以下儿童的皮肤点刺试验结果，研究喘息或过敏性疾病幼儿对常见空气变应原的过敏反应特征。
选取2010年9月1日至12月31日在长沙市某区采样的196名5岁以下儿童，根据是否患有喘息或过敏性疾病分为两组：变应原筛查组（n = 102）和对照组（n = 94）。两组均进行皮肤点刺试验。
变应原筛查组皮肤点刺试验阳性率为61.8%（63/102），显著高于对照组（9.6%，9/94；P<0.05）。在变应原筛查组中，反复喘息合并过敏性鼻炎患儿的皮肤点刺试验阳性率显著高于单纯喘息患儿（P<0.05）。喘息频率与皮肤点刺试验阳性呈正相关（r = 0.91；P<0.05）。变应原筛查组中，螨的皮肤点刺试验阳性率显著高于其他空气变应原（24.2% 对3.5%；P<0.05）。儿童对粉尘螨的皮肤点刺试验阳性率高于屋尘螨（50.0% 对14.7%；P<0.05）。
幼儿喘息可能与哮喘的发生有关。皮肤点刺试验有助于诊断过敏性疾病，并评估喘息儿童对空气变应原的过敏反应。
