Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Greece.
Am J Cardiovasc Drugs. 2012 Jun 1;12(3):143-56. doi: 10.2165/11599040-000000000-00000.
Arterial stiffness is an independent predictor of cardiovascular (CV) morbidity and mortality in patients with hypertension, as well as a potential therapeutic target. There is increasing awareness that the pulsatile hemodynamics (central blood pressure [CBP], pulse pressure [PP], wave reflections [augmentation index or AIx] and pulse wave velocity [PWV]) may provide better insight into the pathophysiology of CV disorders and target organ damage related to hypertension. Different antihypertensive drugs produce diverse effects on arterial stiffness variables, despite similar effects on peripheral (brachial) blood pressure. Identifying the pharmacologic interventions that can improve arterial stiffness ('de-stiffening' treatment) is a promising field of research.
动脉僵硬度是高血压患者心血管（CV）发病率和死亡率的独立预测因子，也是一个潜在的治疗靶点。人们越来越意识到脉动血流动力学（中心血压[CBP]、脉压[PP]、波反射[增强指数或 AIx]和脉搏波速度[PWV]）可能更深入地了解与高血压相关的 CV 紊乱和靶器官损伤的病理生理学。尽管不同的降压药物对外周（肱）血压有相似的作用，但它们对动脉僵硬度变量的影响却不同。确定能够改善动脉僵硬度的药物干预措施（“去僵治疗”）是一个很有前途的研究领域。
