Frank J A, Choyke P L, Girton M E, Morrison P, Diggs R, Skinner M
Diagnostic Radiology Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892.
Invest Radiol. 1990 Nov;25(11):1212-6. doi: 10.1097/00004424-199011000-00010.
The total body clearance of gadopentetate dimeglumine (Gd-DTPA) was evaluated in 17 normal rabbits and 11 rabbits with renal insufficiency induced by angioinfarction. Serial measurements of the serum spin lattice relaxation rate (1/T1) were compared with actual gadolinium concentrations as determined by mass spectroscopy. Gadopentetate dimeglumine concentrations measured by both mass spectroscopy and magnetic resonance (MR) relaxometry decreased by two logs in both normals and rabbits with renal impairment by 24 hours and were highly correlated with each other (r = .98). The estimated total body clearance of gadopentetate dimeglumine was 14.1 +/- 0.56 cc/minute for the normal animals and 3.78 +/- 0.19 cc/minute for the impaired rabbits. These results indicate that gadopentetate dimeglumine is excreted rapidly, usually within 24 hours, even in the presence of renal insufficiency.
在17只正常兔和11只由血管梗塞诱导的肾功能不全兔中评估了钆喷酸葡胺（Gd-DTPA）的全身清除率。将血清自旋晶格弛豫率（1/T1）的系列测量值与通过质谱法测定的实际钆浓度进行比较。通过质谱法和磁共振（MR）弛豫测量法测得的钆喷酸葡胺浓度在正常兔和肾功能受损兔中在24小时内均下降了两个对数，并且彼此高度相关（r = 0.98）。正常动物钆喷酸葡胺的估计全身清除率为14.1±0.56毫升/分钟，受损兔为3.78±0.19毫升/分钟。这些结果表明，即使存在肾功能不全，钆喷酸葡胺也能迅速排泄，通常在24小时内。
