钆配合物增强椎间盘：动物模型中离子型与非离子型介质的比较
Enhancement of intervertebral disks with gadolinium complexes: comparison of an ionic and a nonionic medium in an animal model.
作者信息
Ibrahim M A, Haughton V M, Hyde J S
机构信息
Biophysics Research Institute, Medical College of Wisconsin, Milwaukee 53226.
出版信息
AJNR Am J Neuroradiol. 1994 Nov;15(10):1907-10.
PURPOSE
To compare MR contrast enhancement of intervertebral disk tissue after intravenous administration of equimolar doses of an ionic and of a nonionic gadolinium complex.
METHODS
Contrast enhancement was measured on MR in lumbar intervertebral disks for 120 minutes after intravenous injection of gadoteridol or gadopentetate dimeglumine, 0.3 mmol/kg. MR studies were performed with each contrast medium in four rabbits. Contrast enhancement was measured in intervertebral disks as a function of time and contrast medium.
RESULTS
With both contrast media, enhancement of normal intervertebral disks was detected. Enhancement of disks was significantly greater with gadoteridol than with gadopentetate dimeglumine.
CONCLUSION
The enhancement of cartilage is influenced by the molecular structure of the gadolinium complex. The negative charge of gadopentetate dimeglumine may give it a slower rate of diffusion into disk cartilage than a nonionic complex.
目的
比较静脉注射等摩尔剂量的离子型和非离子型钆复合物后椎间盘组织的磁共振对比增强情况。
方法
静脉注射钆特醇或钆喷酸葡胺（0.3 mmol/kg）后，在腰椎间盘进行120分钟的磁共振对比增强测量。对4只兔子分别使用每种对比剂进行磁共振研究。测量椎间盘的对比增强情况，并将其作为时间和对比剂的函数。
结果
使用两种对比剂均检测到正常椎间盘的增强。钆特醇组椎间盘的增强明显大于钆喷酸葡胺组。
结论
钆复合物的分子结构会影响软骨的增强。钆喷酸葡胺的负电荷可能使其扩散到椎间盘软骨中的速度比非离子型复合物慢。
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