Institute of Anatomy, University of Veterinary Medicine and Pharmacy, Kosice, Slovak Republic.
J Environ Sci Health A Tox Hazard Subst Environ Eng. 2012;47(9):1312-8. doi: 10.1080/10934529.2012.672138.
Developmental data of carbamate pesticides are scarce although they generally possess low toxicity for vertebrates. The aim of the study was to investigate the toxicity of bendiocarb to liver and central nervous system of chick embryos. Bendiocarb (1600 μg/egg) was administered to the embryo through membrana papyracea on embryonic day 3 and 10. In the liver and central nervous system we observed no macroscopic or microscopic changes. These organs were also investigated for caspase activity in regard to application of bendiocarb and no differences in the caspase immunopositivity were observed in comparison with the control. The embryolethality after bendiocarb respective dose was high (94 %) on the embryonic day 3, though following results indicated no toxicity to investigated organs and no increase in the number of apoptotic cells in survived chick embryos on both the early (day 3 of incubation) and the later (day 10 of incubation) developmental stage.
尽管氨基甲酸酯类农药对脊椎动物一般具有低毒性，但有关其发育数据却十分有限。本研究的目的是研究丁醚脲对鸡胚肝脏和中枢神经系统的毒性。丁醚脲（1600μg/卵）于胚胎第 3 天和第 10 天通过 Papyrus 膜施用于胚胎。在肝脏和中枢神经系统中，我们未观察到宏观或微观变化。还针对丁醚脲的应用研究了这些器官中的胱天蛋白酶活性，与对照组相比，胱天蛋白酶免疫阳性无差异。丁醚脲相应剂量在胚胎第 3 天的胚胎致死率很高（94%），但以下结果表明，在存活的鸡胚中，未观察到所研究的器官毒性，并且在早期（孵育第 3 天）和后期（孵育第 10 天）发育阶段，凋亡细胞数量均无增加。
