Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore 21228, USA.
Clin Neurophysiol. 2012 Oct;123(10):1980-8. doi: 10.1016/j.clinph.2012.03.011. Epub 2012 Apr 25.
Theta-alpha range oscillations have been associated with MMN in healthy controls. Our previous studies showed that theta-alpha activities are highly heritable in schizophrenia patients' families. We aimed to test the hypothesis that theta-alpha activities may contribute to MMN in schizophrenia patients and their family members.
We compared MMN and single trial oscillations during MMN in 95 patients, 75 first-degree relatives, 87 controls, and 34 community subjects with schizophrenia spectrum personality (SSP) traits.
We found that (1) MMN was reduced in patients (p<0.001) and SSP subjects (p=0.047) but not in relatives (p=0.42); (2) there were augmented 1-20 Hz oscillations in patients (p=0.02 to <0.001) during standard and deviant stimuli; (3) theta-alpha (5-12 Hz) oscillations had the strongest correlation to MMN in controls and relatives (ΔR(2)=21.4-23.9%, all p<0.001), while delta (<5 Hz) showed the strongest correlation to MMN in schizophrenia and SSP trait subjects; and, (4) MMN (h(2)=0.56, p=0.002) and theta-alpha (h(2)=0.55, p=0.004) were heritable traits.
Low frequency oscillations have a robust relationship with MMN and the relationship appears altered by schizophrenia; and schizophrenia patients showed augmented low frequency activities during the MMN paradigm.
The results encourage investigation of low frequency oscillations to elucidate the neurophysiological pathology underlying MMN abnormalities in schizophrenia.
θ-α 频段振荡与健康对照者的 MMN 有关。我们之前的研究表明，θ-α 活动在精神分裂症患者家庭中具有高度遗传性。我们旨在检验以下假设：θ-α 活动可能导致精神分裂症患者及其家庭成员的 MMN。
我们比较了 95 名患者、75 名一级亲属、87 名对照者以及 34 名具有精神分裂症谱系人格特质（SSP）的社区受试者的 MMN 和 MMN 期间的单个试验振荡。
我们发现：（1）患者（p<0.001）和 SSP 受试者（p=0.047）的 MMN 减少，但亲属中未减少（p=0.42）；（2）在标准和偏差刺激期间，患者的 1-20 Hz 振荡增强（p=0.02 至<0.001）；（3）θ-α（5-12 Hz）振荡与对照组和亲属的 MMN 相关性最强（ΔR(2)=21.4-23.9%，均 p<0.001），而在精神分裂症和 SSP 特质受试者中，δ（<5 Hz）与 MMN 的相关性最强；（4）MMN（h(2)=0.56，p=0.002）和 θ-α（h(2)=0.55，p=0.004）是可遗传的特征。
低频振荡与 MMN 具有很强的关系，这种关系似乎因精神分裂症而改变；并且精神分裂症患者在 MMN 范式期间表现出增强的低频活动。
这些结果鼓励对低频振荡进行研究，以阐明精神分裂症中 MMN 异常的神经生理病理学。
