Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy.
Carbohydr Res. 2012 Jun 1;354:21-31. doi: 10.1016/j.carres.2012.03.002. Epub 2012 Mar 17.
Magnetic Resonance Imaging (MRI) using paramagnetic systems as contrast agents is receiving increased attention as diagnostic tool in the clinic. At the same time, NMR of paramagnetic systems can also be applied in biochemical fields; for example, the use of Paramagnetic Relaxation Enhancement (PRE) allows structure refinement and the analysis of transient dynamic processes involved in macromolecular complex formation. Herein we report the synthesis and computational characterization of a new DOTA-like sialic acid conjugate, which can be used both in MRI and PRE applications when coordinated to a suitable paramagnetic metal.
磁共振成像（MRI）使用顺磁系统作为对比剂，作为诊断工具在临床上受到越来越多的关注。同时，顺磁系统的 NMR 也可以应用于生化领域；例如，使用顺磁弛豫增强（PRE）可以进行结构细化和分析涉及大分子复合物形成的瞬态动态过程。在此，我们报告了一种新的 DOTA 样唾液酸缀合物的合成和计算表征，当与合适的顺磁金属配位时，该缀合物既可以用于 MRI 又可以用于 PRE 应用。
