利用早期预警指标监测中国的 HIV 耐药性：2008 年试点调查结果。

Monitoring HIV drug resistance using early warning indicators in China: results from a pilot survey conducted in 2008.

机构信息

Division of Treatment and Care, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

出版信息

Clin Infect Dis. 2012 May;54 Suppl 4:S300-2. doi: 10.1093/cid/cir1018.

DOI:10.1093/cid/cir1018

PMID:22544191

Abstract

Robust programmatic monitoring of factors associated with the emergence of human immunodeficiency virus (HIV) drug resistance is an essential component of antiretroviral therapy (ART) program evaluation and treatment optimization. China piloted World Health Organization HIV drug resistance early warning indicators to assess the feasibility and usefulness of results. Overall, early warning indicator monitoring showed high levels of appropriate ART prescribing, low rates of loss to follow-up 12 months after ART initiation, and high rates of retention of first-line ART at 12 months. On-time drug pick-up, which may signal treatment interruptions, was identified as a challenge. HIV drug resistance early warning indicator monitoring provides a valuable assessment of ART service delivery, and its application will be scaled up throughout China.

摘要

对与人类免疫缺陷病毒（HIV）耐药性出现相关因素进行强有力的方案监测，是评估抗逆转录病毒治疗（ART）方案和优化治疗的一个重要组成部分。中国对世界卫生组织 HIV 耐药性预警指标进行了试点，以评估结果的可行性和有用性。总体而言，预警指标监测显示了 ART 处方的高适当性、ART 启动后 12 个月的低失访率，以及第 12 个月时一线 ART 的高保留率。按时取药（可能提示治疗中断）被认为是一个挑战。HIV 耐药性预警指标监测为评估 ART 服务提供了一个有价值的工具，其应用将在中国范围内扩大。