State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
Protein Cell. 2012 May;3(5):372-82. doi: 10.1007/s13238-012-2021-x. Epub 2012 Apr 28.
Herpes simplex virus type 1 (HSV-1) is a common human pathogen causing cold sores and even more serious diseases. It can establish a latent stage in sensory ganglia after primary epithelial infections, and reactivate in response to stress or sunlight. Previous studies have demonstrated that viral immediate-early protein ICP0 plays a key role in regulating the balance between lytic and latent infection. Recently, It has been determined that promyelocytic leukemia (PML) nuclear bodies (NBs), small nuclear sub-structures, contribute to the repression of HSV-1 infection in the absence of functional ICP0. In this review, we discuss the fundamentals of the interaction between ICP0 and PML NBs, suggesting a potential link between PML NBs and ICP0 in regulating lytic and latent infection of HSV-1.
单纯疱疹病毒 1 型（HSV-1）是一种常见的人类病原体，可引起唇疱疹，甚至更严重的疾病。它可以在原发性上皮感染后在感觉神经节中建立潜伏期，并在应激或阳光照射下重新激活。以前的研究表明，病毒即刻早期蛋白 ICP0 在调节裂解和潜伏感染之间的平衡中起着关键作用。最近，已经确定早幼粒细胞白血病（PML）核体（NBs），小核亚结构，有助于在没有功能性 ICP0 的情况下抑制 HSV-1 感染。在这篇综述中，我们讨论了 ICP0 与 PML NBs 之间相互作用的基础，提出了 PML NBs 与 ICP0 之间在调节 HSV-1 裂解和潜伏感染中的潜在联系。
