Paul Michael, Jauch Johann
Organic Chemistry II, Am Campus C4.2, Universität des Saarlandes, D-66123 Saarbrücken, Germany.
Nat Prod Commun. 2012 Mar;7(3):283-8.
Incensole and incensole acetate, found in incense, are encouraging potent bioactive diterpenic cembrenoids, inhibiting Nuclear Factor-kappaB activation. Furthermore, incensole acetate elicits psycho-activity in mice by activating the TRPV3 channels in the brain. Starting from crude extracts of the incense species Boswellia papyrifera Hochst., a convenient procedure for the efficient large-scale synthesis of incensole and its acetate is presented. Additionally, a reversed-phase, diode-array-detection, high-performance liquid chromatography (RP-DAD-HPLC) method for the quantification of incensole and incensole acetate is reported, indicating that these two compounds are typical biomarkers for B. papyrifera.
在香薰中发现的沉香醇和乙酸沉香醇是具有潜在生物活性的二萜类西松烷型化合物，可抑制核因子-κB的激活。此外，乙酸沉香醇通过激活大脑中的TRPV3通道在小鼠中引发精神活性。从纸香树（Boswellia papyrifera Hochst.）的粗提物出发，提出了一种高效大规模合成沉香醇及其乙酸酯的简便方法。此外，还报道了一种用于定量沉香醇和乙酸沉香醇的反相二极管阵列检测高效液相色谱（RP-DAD-HPLC）方法，表明这两种化合物是纸香树的典型生物标志物。
