一种用于阴离子的喹啉基双脲受体：硫酸氢根的选择性受体。
A quinoline based bis-urea receptor for anions: a selective receptor for hydrogen sulfate.
作者信息
Russ Tiffany H, Pramanik Avijit, Khansari Maryam E, Wong Bryan M, Hossain Md Alamgir
机构信息
Department of Chemistry and Biochemistry, Jackson State University, 1400 J. R. Lynch Street, P.O. Box 17910, Jackson, MS 39212, USA.
出版信息
Nat Prod Commun. 2012 Mar;7(3):301-4.
A dipodal bis-urea receptor has been synthesized from the reaction of 8-amino quinoline and 1,4-phenylene diisocyanate in dichloromethane, and the anion binding ability of the receptor has been studied using fluoride, chloride, bromide, iodide, perchlorate, nitrate, dihydrogen phosphate and hydrogen sulfate by UV-Vis titrations in DMSO. The results show that the receptor binds each of the anions with a 1:1 stoichiometry, showing high affinity and moderate selectivity for hydrogen sulfate among the anions studied. Ab initio calculations based on density functional theory (DFT) suggest that an anion (X(-)) is bonded within the cleft formed by the two arms of the receptor through two NH...X(-) and two aromatic CH...X(-) interactions. The results from solution and theoretical studies suggest that binding is predominantly influenced by hydrogen bonding interactions and the basicity of anions.
通过8-氨基喹啉与1,4-亚苯基二异氰酸酯在二氯甲烷中的反应合成了一种双足双脲受体，并在二甲基亚砜中通过紫外-可见滴定法，使用氟离子、氯离子、溴离子、碘离子、高氯酸根离子、硝酸根离子、磷酸二氢根离子和硫酸氢根离子研究了该受体的阴离子结合能力。结果表明，该受体与每种阴离子以1:1的化学计量比结合，在所研究的阴离子中对硫酸氢根离子表现出高亲和力和适度选择性。基于密度泛函理论（DFT）的从头算计算表明，阴离子（X(-)）通过两个NH...X(-)和两个芳香族CH...X(-)相互作用在受体两臂形成的裂缝内结合。溶液和理论研究结果表明，结合主要受氢键相互作用和阴离子碱性的影响。
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